Kamlet taft parameters: A tool to alternate the usage of hazardous solvent in pharmaceutical and chemical manufacturing/synthesis - A gateway towards green technology

• Main Authors: Islam, Tariqul, Sarker, Md. Zaidul Islam, Helal Uddin, A.B.M., Kamaruzzaman, Yunus, D.M., Reddy Prasad, Mia, Md. Abdur Rashid, Ferdosh, Sahena
• Format: Article
• Language: English
• Published: Taylors & Francis 2020
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/86335/1/Kamlet-Taft%207.pdf; http://irep.iium.edu.my/86335/; https://www.tandfonline.com/doi/abs/10.1080/22297928.2020.1860124

In chemical synthesis, the uses of solvents are inevitable, and it has been a practice since the inception of the process. With time it gets into the notice that most of the essential solvents have a great potential to cause acute health hazards, which include health-related complications as severe. There was a continuous urge to getting some solution to overcome this problem without compromising the quality of the synthesis process. Kamlet Taft parameter (K-T) is such a tool that can provide detailed information about the solvent characteristics related to the synthesis process thus enabling the selection of the solvent with a lower hazardous index compared with the high one. It has also contributed significantly to tackle environmental hazards by replacing the hazardous dipolar solvent in synthetic chemistry. A solvent pair mixture-Hydrogen bond donor and Hydrogen bond acceptor- is used to replace the routine hazardous solvents. This review aimed at the systematic highlight of the K-T parameters, which will be useful for the selection of suitable solvents for different chemical synthesis, specifically giving importance to drug synthesis. The review will provide insight into the different applications of K-T parameters to ease the comparison of these applications. It will also guide to estimate the solvent effects in synthesis, crystallization, and formulations of pharmaceuticals and bio�pharmaceuticals with systematic classification, analysis, and comparison of the reported work.