Lactoferrin-tethered betulinic acid nanoparticles promote rapid delivery and cell death in triple negative breast and laryngeal cancer cells

• Main Authors: Halder, Asim, Jethwa, Megha, Mukherjee, Pritha, Ghosh, Subarna, Das, Suvadra, Helal Uddin, A.B.M., Mukherjee, Arup, Chatterji, Urmi, Roy, Partha
• Format: Article
• Language: English
• Published: Taylor & Francis 2020
• Subjects: R Medicine (General); RC270 Neoplasms. Tumors. Oncology-Cancer and Other Malignant Neoplasms-Therapeutics; RS Pharmacy and materia medica; RS192 Materia Medica-Pharmaceutical Technology; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/86088/1/Lactoferrin%20tethered%20betulinic%20acid%20nanoparticles%20promote%20rapid%20delivery%20and%20cell%20death%20in%20triple%20negative%20breast%20and%20laryngeal%20cancer%20cells.pdf; http://irep.iium.edu.my/86088/; https://www.tandfonline.com/doi/full/10.1080/21691401.2020.1850465

Cancer management presents multifarious problems. Triple negative breast cancer (TNBC) is associated with inaccurate prognosis and limited chemotherapeutic options. Betulinic acid (BA) prevents angiogenesis and causes apoptosis of TNBC cells. NIH recommends BA for rapid access in cancer chemotherap...