In vitro model of the blood brain barrier

• Main Authors: Mohd Nasir, Mohd Hamzah, Sharif, Mohd. Faez
• Other Authors: Shahar, Saleha
• Format: Book Chapter
• Language: English; English; English; English
• Published: Penerbit UTM Press 2020
• Subjects: Q Science (General); QH301 Biology; QH501 Life
• Online Access: http://irep.iium.edu.my/85567/1/final%20In%20Vitro%20and%20In%20Vivo%20Techniques%20with%20Consideration%20of%20Biological%20System%20%281%29.pdf; http://irep.iium.edu.my/85567/2/Copyright.pdf; http://irep.iium.edu.my/85567/3/Awalan.pdf; http://irep.iium.edu.my/85567/19/Chapter-6.pdf; http://irep.iium.edu.my/85567/

Neurons and other brain cells are extremely sensitive to changes in the macro- and micro-environment especially hydrostatic pressure (intracranial pressure) and electrolyte balance. Therefore, the brain macro- and micro-environment must be strictly maintained to its physiological balance. This can only be achieved by a functional gatekeeper serving as a selective barrier between fluids circulating to and from the brain. There are two primary circulatory fluids in the brain; first is the cerebrospinal fluid (CSF) and second is the blood fluid. Nutrient and biomolecule exchange between the blood and the CSF is regulated by the blood-CSF barrier, located at the choroid plexus. The other barrier that forms a selective permeable interface in the brain environment is the blood-brain barrier (BBB), which will be the primary focus of this chapter.