Evaluation and comparison of Trachyspermum ammi seed extract for its anti-inflammatory effect
Aims and Objectives: The present study was aimed to evaluate the anti-inflammatory effect of different seed extracts of Trachyspermum ammi at different doses. Materials and Methods: Three different seed extracts were prepared through Soxhlet extraction method by using n-hexane, chloroform and met...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Walters Kluwer
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/85392/1/JPBS_Adeel%202020.pdf http://irep.iium.edu.my/85392/ http://www.jpbsonline.org |
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| Summary: | Aims and Objectives: The present study was aimed to evaluate the anti-inflammatory effect of different seed extracts of Trachyspermum ammi at different doses.
Materials and Methods: Three different seed extracts were
prepared through Soxhlet extraction method by using n-hexane, chloroform and methanol solvents. Acute toxicity test performed at dose of 400 mg/kg, 800 mg/kg, 1600 mg/kg and 3200 mg/kg. Two different strengths of seed extracts (minimum therapeutic dose of 500 mg/kg and maximum therapeutic dose of 1000 mg/kg) were given to Wistar rats to measure anti-inflammatory activity through Carrageenan induced paw edema method. Results: The standard drug diclofenac sodium was (percentage of inhibition of paw edema
29.68%) more effective as compared to test drug. When efficacy of all extracts compared with each other, n-hexane extract showed more anti-inflammatory effect (percentage inhibition of paw edema 22.21%) at maximum effective dose
1000 mg/kg. Conclusion: Seed extracts of T. ammi showed anti-inflammatory activity by potentiating the neurotransmission of GABA and also by repression
glutamate receptor. |
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