Formulation development of paracetamol instant jelly for pediatric use
Objective: Paracetamol is a common antipyretic and analgesic medicine used in childhood illness by parents and physicians worldwide. Paracetamol has a bitter taste that is considered as a significant barrier for drug administration. This study aimed to develop an oral dosage form that is palatabl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Taylor and Francis Ltd.
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/84684/1/Formulation%20development%20of%20paracetamol%20instant%20jelly%20for%20pediatric%20use.pdf http://irep.iium.edu.my/84684/7/84684_Formulation%20development%20of%20paracetamol%20instant%20jelly%20for%20pediatric%20use.pdf http://irep.iium.edu.my/84684/ https://www.tandfonline.com/doi/full/10.1080/03639045.2020.1791165?scroll=top&needAccess=true |
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| Summary: | Objective: Paracetamol is a common antipyretic and analgesic medicine used in childhood illness
by parents and physicians worldwide. Paracetamol has a bitter taste that is considered as a
significant barrier for drug administration. This study aimed to develop an oral dosage form that
is palatable and easy to swallow by paediatric patients as well as to overcome the shortcomings
of liquid formulations.
Methods: The paracetamol was encapsulated in beads, which were prepared mainly from
alginate and chitosan through electrospray technique. The paracetamol beads were sprinkled on
the instant jelly prepared from glycine, ι-carrageenan and calcium lactate gluconate. The
paracetamol instant jelly characteristics, in terms of physical appearance, texture, rheology, in
vitro drug release and palatability were assessed on a human volunteer.
Results: The paracetamol instant jelly was easily reconstituted in 20 mL of water within 2 min to
form jelly with acceptable consistency and texture. The jelly must be ingested within 30 min
after reconstitution to avoid the bitter taste. The palatability assessment carried out on 12 human
subjects established the similar palatability and texture of the paracetamol instant jelly dosage
comparable to the commercial paracetamol suspension and was found to be even better in
overcoming the aftertaste of paracetamol.
Conclusion: Such findings indicate that paracetamol instant jelly will compensate for the use of
sweetening and flavouring agents as well as develop paediatric dosage forms with limited
undesired excipients. |
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