Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152

• Main Authors: Thompson, Michael J., Abdul Rahman, Suzanah, Baker, Theresa G., Bibby, Michael Charles
• Format: Article
• Language: English
• Published: Elsevier 1996
• Subjects: RA1190 Toxicology; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/8409/1/Reprod_Tox_1996_Suzanah.pdf; http://irep.iium.edu.my/8409/; http://www.journals.elsevier.com/reproductive-toxicology/

Alkylating agents are a group of compounds that have a cytotoxic effect due to their ability to form adducts with DNA. Cells possess the ability to repair this damage via an enzyme, O6-alkylguanine-DNA alkyltransferase (AGT). To study the effect of inhibiting this repair mechanism upon testicular cy...