Genotypic to phenotypic resistance discrepancies identified involving Β-lactamase genes, blaKPC, blaiMP, blaNDM-1, and blaVIM in uropathogenic Klebsiella pneumoniae

• Main Authors: Urmi, Umme Laila, Nahar, Shamsun, Rana, Masud, Sultana, Fahmida, Jahan, Nusrat, Hossain, Billal, Alam, Mohammed Shah, Md Mosaddek, Abu Syed, McKimm, Judy, A. Rahman, Nor Azlina, Islam, Salequl, Haque, Mainul
• Format: Article
• Language: English; English; English
• Published: Dove Medical Press Limited 2020
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/83262/1/2020-5%20Uropathogenic%20K.pneumonia%20genotypic.pdf; http://irep.iium.edu.my/83262/8/83262_Genotypic%20to%20Phenotypic%20Resistance%20Discrepancies_scopus.pdf; http://irep.iium.edu.my/83262/7/83262_Genotypic%20to%20Phenotypic%20Resistance%20Discrepancies_wos.pdf; http://irep.iium.edu.my/83262/; https://www.dovepress.com/genotypic-to-phenotypic-resistance-discrepancies-identified-involving--peer-reviewed-fulltext-article-IDR; https://doi.org/10.2147/IDR.S262493

Introduction: Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions...