The decisive study: defining beta-lactam concentration in Intensive care unit patients.

• Main Authors: Mat Nor, Mohd Basri, Mazlan, Mohd Zulfakar, Sulaiman, Helmi, Kamarulzaman, Adeeba, Hasan, Mohd Shahnaz, Wan Mat, Wan Rahiza
• Format: Monograph
• Language: English
• Published: International Islamic University Malaysia 2020
• Subjects: RM147 Administration of Drugs and Other Therapeutic Agents
• Online Access: http://irep.iium.edu.my/82560/1/Research%20Report%20FRGS%202016-1_Basri.pdf; http://irep.iium.edu.my/82560/

Summary of Research Findings: 1. Patients age, estimated CLcr and recent surgery significantly predicted the Vd and CL of both beta-lactams. Piperacillin and meropenem concentrations were highly-variable with coefficient of variation (COV) of ≥67.7%. Forty-nine patients (58.3%) achieved the PK/PD t...