Computational quest for finding potential Ebola VP40 inhibitors: a molecular docking study = [pencarian pengiraan untuk mencari potensi perencat Ebola VP40: suatu kajian mengedok molekul]

• Main Authors: Mohamad Yussoff, Mohamad Ariff, Abdul Hamid, Azzmer Azzar, Abd Hamid, Shafida, Abd Halim, Khairul Bariyyah
• Format: Article
• Language: English; English
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Subjects: Q Science (General); QD Chemistry; TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/82230/1/82230_Computational%20Quest%20for%20Finding%20Potential%20Ebola%20VP40%20Inhibitors_full%20text.pdf; http://irep.iium.edu.my/82230/2/82230_Computational%20Quest%20for%20Finding%20Potential%20Ebola%20VP40%20Inhibitors_scopus.pdf; http://irep.iium.edu.my/82230/; http://www.ukm.edu.my/jsm/pdf_files/SM-PDF-49-3-2020/ARTIKEL%208.pdf

Interaction of Ebola virus matrix protein VP40 with RNA is crucial in the early infection stage to facilitate the transcription of the viral gene. Thus, VP40 is a promising target to inhibit the Ebola virus from spreading. This study aims to identify and optimize ligands that can potentially block t...