Adducin methylation and blood pressure in young adults ; less is more
Background: Essential hypertension is a multifaceted disease implicating both genetic, environment and epigenetic modification. Whilst -Adducin (ADD1) polymorphism in essential hypertension has been previously described, modification in DNA methylation of ADD1 gene in hypertensive young adults is n...
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my.iium.irep.820032020-08-07T08:46:56Z http://irep.iium.edu.my/82003/ Adducin methylation and blood pressure in young adults ; less is more Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin QP Physiology RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Background: Essential hypertension is a multifaceted disease implicating both genetic, environment and epigenetic modification. Whilst -Adducin (ADD1) polymorphism in essential hypertension has been previously described, modification in DNA methylation of ADD1 gene in hypertensive young adults is not known. Objective: To evaluate the association between ADD1 methylation and blood pressure in hypertensive young adults. Materials and methods: A cross-sectional study involving 80 normotension and 80 incident hypertension aged 18 to 45 years was conducted in Kuantan, Pahang. Subjects were recruited via purposive sampling according to blood pressure status. Anthropometric measurements and biochemical parameters (glycemic index, lipid profile, high- sensitivity C-reactive protein) were examined. ADD1 methylation in peripheral blood were assessed using MethyLight assay. Results: There were inverse correlation significant between ADD1 methylation and systolic blood pressure (p = 0.006, r = –0.240), diastolic blood pressure (p = 0.001, r= –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive young adults had significantly lower ADD1 methylation compared to normotensive controls (p = 0.005). After controlling for other baseline covariates, ADD1 methylation proved to be a significant predictor for hypertension in young adults (p = 0.020). Conclusion: In young adults, ADD1 methylation predicted hypertension. Thus, ADD1 methylation could serve as a future preventive and therapeutic target for hypertension, upkeeping the precision medicine notion. 2020-02-14 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/82003/1/MSH%202020%20ppt%20in%20PDF.pdf application/pdf en http://irep.iium.edu.my/82003/2/MSH%20cover%20book.jpeg application/pdf en http://irep.iium.edu.my/82003/3/MSH%20schedule.jpeg application/pdf en http://irep.iium.edu.my/82003/5/MSH%202020%20Certificate%20of%20YIA%20Winner%20-%20First%20Prize.pdf application/pdf en http://irep.iium.edu.my/82003/28/MSH%20abstract%20page.jpeg Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2020) Adducin methylation and blood pressure in young adults ; less is more. In: Malaysian Society of Hypertension17th Annual Congress 2020, Shangri-La Hotel, Kuala Lumpur, Malaysia. |
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QP Physiology RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin Adducin methylation and blood pressure in young adults ; less is more |
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Background: Essential hypertension is a multifaceted disease implicating both genetic, environment and epigenetic modification. Whilst -Adducin (ADD1) polymorphism in essential hypertension has been previously described, modification in DNA methylation of ADD1 gene in hypertensive young adults is not known.
Objective: To evaluate the association between ADD1 methylation and blood pressure in hypertensive young adults.
Materials and methods: A cross-sectional study involving 80 normotension and 80 incident hypertension aged 18 to 45 years was conducted in Kuantan, Pahang. Subjects were recruited via purposive sampling according to blood pressure status. Anthropometric measurements and biochemical parameters (glycemic index, lipid profile, high- sensitivity C-reactive protein) were examined. ADD1 methylation in peripheral blood were assessed using MethyLight assay.
Results: There were inverse correlation significant between ADD1 methylation and systolic blood pressure (p = 0.006, r = –0.240), diastolic blood pressure (p = 0.001, r= –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive young adults had significantly lower ADD1 methylation compared to normotensive controls (p = 0.005). After controlling for other baseline covariates, ADD1 methylation proved to be a significant predictor for hypertension in young adults (p = 0.020).
Conclusion: In young adults, ADD1 methylation predicted hypertension. Thus, ADD1 methylation could serve as a future preventive and therapeutic target for hypertension, upkeeping the precision medicine notion. |
format |
Conference or Workshop Item |
author |
Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin |
author_facet |
Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin |
author_sort |
Wan Omar, Wan Fatein Nabeila |
title |
Adducin methylation and blood pressure in young adults ; less is more |
title_short |
Adducin methylation and blood pressure in young adults ; less is more |
title_full |
Adducin methylation and blood pressure in young adults ; less is more |
title_fullStr |
Adducin methylation and blood pressure in young adults ; less is more |
title_full_unstemmed |
Adducin methylation and blood pressure in young adults ; less is more |
title_sort |
adducin methylation and blood pressure in young adults ; less is more |
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2020 |
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http://irep.iium.edu.my/82003/1/MSH%202020%20ppt%20in%20PDF.pdf http://irep.iium.edu.my/82003/2/MSH%20cover%20book.jpeg http://irep.iium.edu.my/82003/3/MSH%20schedule.jpeg http://irep.iium.edu.my/82003/5/MSH%202020%20Certificate%20of%20YIA%20Winner%20-%20First%20Prize.pdf http://irep.iium.edu.my/82003/28/MSH%20abstract%20page.jpeg http://irep.iium.edu.my/82003/ |
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