Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters

INTRODUCTION :Pre-bed dosing of L-thyroxine is an alternative method to improve patient’s compliance especially in the month of Ramadan. However some studies reported the increment of Thyroid Stimulating Hormone (TSH) on Pre-bed dosing suggesting Subclinical Hypothyroidism(SH). Dyslipidemia is one...

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Main Authors: Zakaria, Nurul Aulia, Shahar, Mohammad Arif
Format: Conference or Workshop Item
Language:English
English
Published: 2019
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Online Access:http://irep.iium.edu.my/81836/1/KRD%20ThyRa%20Lipid.pdf
http://irep.iium.edu.my/81836/7/krd2019.pdf
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spelling my.iium.irep.818362020-08-03T07:40:01Z http://irep.iium.edu.my/81836/ Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters Zakaria, Nurul Aulia Shahar, Mohammad Arif RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology INTRODUCTION :Pre-bed dosing of L-thyroxine is an alternative method to improve patient’s compliance especially in the month of Ramadan. However some studies reported the increment of Thyroid Stimulating Hormone (TSH) on Pre-bed dosing suggesting Subclinical Hypothyroidism(SH). Dyslipidemia is one of the marker for tissue hypothyroidism. However, the relationship between Subclinical Hypothyroidism (SH) and lipid metabolism is still debatable.OBJECTIVE :We would like to investigate the effect of Pre-bed thyroxine ingestion during the month of Ramadan towards thyroid hormones and lipid parameters. METHOD : A total of 9 hypothyroid patients who are on daily L-thyroxine replacement (taken before breakfast) with a normal baseline thyroid hormones and lipid profile were involved in this study. During Ramadan, they were asked to take their daily dose of L-thyroxine pre-bed instead of taking it pre-breakfast. At the end of Ramadan, their thyroid hormones and lipid profile were analysed. RESULTS : Most of the patients were already on thyroxine for more than a year with a stable dose of L-thyroxine . Their thyroid hormones (TSH,fT3,fT4) and lipid profile (TC, LDL, HDL,triglyceride) were within normal range at presentation. At the end of Ramadan, there was a significant increment of TSH observed [TSH w0 1.8(0.23,5.57) vs w4 3.65(0.45,16.10) p=0.011] without significant change of fT3 and fT4 which indicate SH. However , there were no significant change in the lipid parameters at the end of Ramadan despite biochemically being SH. CONCLUSION :Pre bed dosing biochemically showed to cause Subclinical Hypothyroidsim(SH).However, no effect on lipid metabolism were observed to indicate tissue hypothyroidism in SH. 2019-10-23 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/81836/1/KRD%20ThyRa%20Lipid.pdf application/pdf en http://irep.iium.edu.my/81836/7/krd2019.pdf Zakaria, Nurul Aulia and Shahar, Mohammad Arif (2019) Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters. In: Kuantan Research Day 2019, 23rd October 2019, Kuantan, Pahang. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
spellingShingle RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Zakaria, Nurul Aulia
Shahar, Mohammad Arif
Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
description INTRODUCTION :Pre-bed dosing of L-thyroxine is an alternative method to improve patient’s compliance especially in the month of Ramadan. However some studies reported the increment of Thyroid Stimulating Hormone (TSH) on Pre-bed dosing suggesting Subclinical Hypothyroidism(SH). Dyslipidemia is one of the marker for tissue hypothyroidism. However, the relationship between Subclinical Hypothyroidism (SH) and lipid metabolism is still debatable.OBJECTIVE :We would like to investigate the effect of Pre-bed thyroxine ingestion during the month of Ramadan towards thyroid hormones and lipid parameters. METHOD : A total of 9 hypothyroid patients who are on daily L-thyroxine replacement (taken before breakfast) with a normal baseline thyroid hormones and lipid profile were involved in this study. During Ramadan, they were asked to take their daily dose of L-thyroxine pre-bed instead of taking it pre-breakfast. At the end of Ramadan, their thyroid hormones and lipid profile were analysed. RESULTS : Most of the patients were already on thyroxine for more than a year with a stable dose of L-thyroxine . Their thyroid hormones (TSH,fT3,fT4) and lipid profile (TC, LDL, HDL,triglyceride) were within normal range at presentation. At the end of Ramadan, there was a significant increment of TSH observed [TSH w0 1.8(0.23,5.57) vs w4 3.65(0.45,16.10) p=0.011] without significant change of fT3 and fT4 which indicate SH. However , there were no significant change in the lipid parameters at the end of Ramadan despite biochemically being SH. CONCLUSION :Pre bed dosing biochemically showed to cause Subclinical Hypothyroidsim(SH).However, no effect on lipid metabolism were observed to indicate tissue hypothyroidism in SH.
format Conference or Workshop Item
author Zakaria, Nurul Aulia
Shahar, Mohammad Arif
author_facet Zakaria, Nurul Aulia
Shahar, Mohammad Arif
author_sort Zakaria, Nurul Aulia
title Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
title_short Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
title_full Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
title_fullStr Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
title_full_unstemmed Pre-bed dosing of L-thyroxine in Ramadan and the effect on lipid parameters
title_sort pre-bed dosing of l-thyroxine in ramadan and the effect on lipid parameters
publishDate 2019
url http://irep.iium.edu.my/81836/1/KRD%20ThyRa%20Lipid.pdf
http://irep.iium.edu.my/81836/7/krd2019.pdf
http://irep.iium.edu.my/81836/
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score 13.211869