Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
Purpose: To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods: This is a cross-sectional study that took place in a Malaysi...
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my.iium.irep.799132020-05-10T13:45:28Z http://irep.iium.edu.my/79913/ Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan R Medicine (General) RA Public aspects of medicine RS Pharmacy and materia medica Purpose: To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods: This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders. Results: Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL. Conclusion: PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument. © 2019, Springer Nature Switzerland AG. Springer International Publishing 2019-07-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79913/1/79913_Does%20inappropriate%20prescribing_MYRA.pdf application/pdf en http://irep.iium.edu.my/79913/2/79913_Does%20inappropriate%20prescribing_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/79913/3/79913_Does%20inappropriate%20prescribing_WOS.pdf Akkawi, Muhammad Eid and Nik Mohamed, Mohamad Haniki and Md Aris, Mohd Aznan (2019) Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital. Quality of Life Research, 28 (7). pp. 1913-1920. ISSN 0962-9343 E-ISSN 1573-2649 https://link.springer.com/article/10.1007/s11136-019-02153-5 10.1007/s11136-019-02153-5 |
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R Medicine (General) RA Public aspects of medicine RS Pharmacy and materia medica Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
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Purpose: To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods: This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders. Results: Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL. Conclusion: PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument. © 2019, Springer Nature Switzerland AG. |
format |
Article |
author |
Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan |
author_facet |
Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan |
author_sort |
Akkawi, Muhammad Eid |
title |
Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
title_short |
Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
title_full |
Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
title_fullStr |
Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
title_full_unstemmed |
Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital |
title_sort |
does inappropriate prescribing affect elderly patients’ quality of life? a study from a malaysian tertiary hospital |
publisher |
Springer International Publishing |
publishDate |
2019 |
url |
http://irep.iium.edu.my/79913/1/79913_Does%20inappropriate%20prescribing_MYRA.pdf http://irep.iium.edu.my/79913/2/79913_Does%20inappropriate%20prescribing_SCOPUS.pdf http://irep.iium.edu.my/79913/3/79913_Does%20inappropriate%20prescribing_WOS.pdf http://irep.iium.edu.my/79913/ https://link.springer.com/article/10.1007/s11136-019-02153-5 |
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