Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

Two-pore domain K+ (K2P) channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/KCNK1) K2P channel remain poorly characterized because heterologous expression of this ion channel yields only very low levels of functional activity. Several under...

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Bibliographic Details
Main Authors: Nematian-Ardestani, Ehsan, Abd. Wahab, Mohd. Firdaus, Chatelain, Franck C., Sun, Han, Schewe, Marcus, Baukrowitz, Thomas, Tucker, Stephen J.
Format: Article
Language:English
English
English
English
Published: American Society for Biochemistry and Molecular Biology Publications 2020
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Online Access:http://irep.iium.edu.my/79624/1/79624_Selectivity%20filter%20instability%20dominates%20-%20pre-print.pdf
http://irep.iium.edu.my/79624/2/79624_Selectivity%20filter%20instability%20dominates_MYRA.pdf
http://irep.iium.edu.my/79624/3/79624_Selectivity%20filter%20instability%20dominates_SCOPUS.pdf
http://irep.iium.edu.my/79624/4/79624_Selectivity%20filter%20instability%20dominates_WOS.pdf
http://irep.iium.edu.my/79624/
https://www.jbc.org/content/295/2/610.short
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