Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

• Main Authors: Murugesu, Suganya, Ibrahim, Zalikha, Ahmed, Qamar Uddin, Uzir, Bisha Fathamah, Nik Yusoff, Nik Mohd. Idris, Perumal, Vikneswari, Abas, Faridah, Shaari, Khozirah, Khatib, Alfi
• Format: Article
• Language: English; English
• Published: Xi'an Jiaotong University 2019
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/79140/1/Murugesu%20et%20al%202019-JPA.pdf; http://irep.iium.edu.my/79140/7/scopus_79140.pdf; http://irep.iium.edu.my/79140/; https://www.sciencedirect.com/science/article/pii/S2095177918304659?via%3Dihub

The present study used in vitro and in silico techniques, as well as the metabolomics approach to characterise α-glucosidase inhibitors from different fractions of Clinacanthus nutans. C. nutans is a medicinal plant belonging to the Acanthaceae family, and is traditionally used to treat diabetes in...