Experimental oral candidiasis in wistar rat model

• Main Author: Mustafa Al-Ahmad, Basma Ezzat
• Format: Conference or Workshop Item
• Language: English; English; English; English; English
• Published: 2019
• Subjects: RK Dentistry
• Online Access: http://irep.iium.edu.my/76569/1/dental%20malaysia.jpg; http://irep.iium.edu.my/76569/9/76569_Experimental%20oral%20candidiasis%20in%20wistar%20rat%20model.pdf; http://irep.iium.edu.my/76569/20/76569_Tentative%20Program%20Cover.pdf; http://irep.iium.edu.my/76569/21/76569_Tentative%20Program.pdf; http://irep.iium.edu.my/76569/10/76569_Certificate.pdf; http://irep.iium.edu.my/76569/

The human oral cavity is a unique ecological niche because it is constantly bathed in saliva, a biological fluid with antifungal and antibacterial activity. In addition, the constant salivary flushing action mechanically inhibits the accumulation of microorganisms in various oral niches. The rat model is well proven for observing oral candidal colonization and infection, due to the ease of breeding, handling and their ready availability. Candida is a normal commensal of mucous membrane of human mouth. One of the most prevalent manifestations of oral candidiasis is candida- induced denture stomatitis. A major virulence factor of candida albicans is its ability to adapt to different environments, the resulting is formation of surface-attached microbial communities known as biofilms. The treatment of mucosal infections caused by candida and the elucidation of the disease is challenging.