Infections by multidrug-resistant Gram-negative bacteria: what's new in our arsenal and what's in the pipeline?

• Main Authors: Koulenti, Despoina, Song, Andrew, Ellingboe, Aaron, Abdul-Aziz, Mohd Hafiz, Harris, Patrick, Gavey, Emile S., Lipman, Jeffrey
• Format: Article
• Language: English; English; English
• Published: Elsevier B.V. 2019
• Subjects: RA Public aspects of medicine; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/76366/1/76366_Infections%20by%20multidrug-resistant_article.pdf; http://irep.iium.edu.my/76366/2/76366_Infections%20by%20multidrug-resistant_scopus.pdf; http://irep.iium.edu.my/76366/3/76366_Infections%20by%20multidrug-resistant_wos.pdf; http://irep.iium.edu.my/76366/; https://pdf.sciencedirectassets.com/271247/1-s2.0-S0924857919X00035/1-s2.0-S0924857918303030/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEJH%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQCSWsUMEpWU5sWEvQjUxqep4fhkcINDiitOiQs4OoEFswIhAKfgMbuYBi2TG7RjX8eX%2BHN85BbUbBBa8sgJBTYXSaWiKtgCCLr%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQAhoMMDU5MDAzNTQ2ODY1Igzut%2FVoLbH6VN%2Ftqj4qrAKq2SmVsP%2FvVcC1CLlHGuFevqpjDsQA%2BqSpG%2Fmqhka8FPQfi1RdLs2Snun4GiYbjc5N%2BV7is6QjK5OWNrqhXrw1RrjT6mIcX9MvdiuQrr%2FHaDlzN%2FLXV8SXEKVd%2FsImuXB76zC%2B%2BDjKkf%2F9X5UlTDTWRW%2FSwQmyEBKKFMO2SuATOE8rSie%2Bo9E6NeiZ1Isi19SsRG6KqVcem9DcRJjXV2EqJLUU%2FxWv5i32HXEEjZ%2BvKOTj25tZw4zucESoVSUNHvX5dmQfj%2FCmqcRJEZkgKjCJDkUfMpNoz83VZBLP27VwLpBQwPo0P1x9rsHl95EhJWUWG8xJXQTtuxZ9U4SbVelN73ud%2FEnjRnKCmWgsGuUyLZ1K5qyPa0McfJj5OCmqrX9GbEOm%2FO1fHfD8FvUwzdfO7gU6zwKMpXkL3mTrP%2B0zu7zuSsb1DoUY%2Fjr9DSn9MavmYGn6YSRbZC%2FIPE%2F5tzi%2F6DNogcU5ALhW8ss9dVxPcmXe0Vvo3bw7NRf5Qm79vwKTMV8OlgYW01dbajC%2BepvNQBCQTAYwFAv06EjwMUvDRkX8qdicoBQSE70s9fpRtAD%2BvUL9MyR8TzCwJkM3daBj3quhfspeYx3VbACEiJTqpsEhTMXjxPiFPivJ16AOrec115Pbz%2FCc3Pfy04fd1bPGNPj57WW%2FAn7pn1TRd0zbII6PnfYy2FEC%2FzUPNpyB7mEBzZRKki9qmr9%2BMkoSTcESBdJcqPSz1NxVOQ%2BxB0PdXtcRC2KL4QA4kDmnBhSzZjwYbB1VigaJLKhPe2MjuOT9Znx7RRiI0L46T6Ab%2FYjBp1M%2BfUzDC93sXlRCiW2lHADEG6HXAxzCDMpmt8rMqmEVkfYy3w%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20191119T101311Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYZ6ZYRQ6G%2F20191119%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=48b722079b4b4cd8f4f5d7bd52c0b6c792b0dbf49124e05eb7cebad048cc3e4e&hash=89d0515c66fdd9807ae44d94de051d6dc8f6f8574fd4398573756780b9d26d8d&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0924857918303030&tid=spdf-8a42cfc2-ba12-496a-951d-d6eb7007bc4d&sid=8977bc7c4a84344a1f79b7d7eeec717283c2gxrqb&type=client

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire and spread new resistance mechanisms. Treating infections caused by Gram-negative bacteria is a challenge for medical...