Effects of flaxseed extract on skin wound healing in animal model

• Main Authors: Abdul Jabbar, Omar, Kashmoola, Muhannad Ali, Mustafa Al-Ahmad, Basma Ezzat, Mokhtar@Makhtar, Khairani Idah, Muhammad, Siti Aeshah @ Naznin, Abdul Rahim, Roslina, Nazri, Aliah
• Format: Conference or Workshop Item
• Language: English; English; English
• Published: 2019
• Subjects: R Medicine (General); RB Pathology
• Online Access: http://irep.iium.edu.my/75490/17/75490_ICPRP%202019%20%28Cover%29.pdf; http://irep.iium.edu.my/75490/18/75490_ICPRP%202019%20%28Program%20Book%29.pdf; http://irep.iium.edu.my/75490/27/75490_ICPRP%202019%20%28Slide%29.pdf; http://irep.iium.edu.my/75490/

INTRODUCTION Wound healing is a complex process which requires special factors and condition. It includes phases such as cell migration, extracellular matrix deposition, remodeling, and angiogenesis. Drugs which accelerate wound healing are expanded, particularly herbal drugs which mainly safe and effective. OBJECTIVES The present study was conducted to evaluate wound healing activity of flaxseed oil on experimentally induced incision wounds, according to histopathological parameters. METHOD The flaxseed oil was prepared according to standard ethanol extraction protocol and was applied to wound. Twenty-seven male New Zealand rabbits were randomly divided into three groups of 9 rabbits: Flaxseed treated (study group), 2% Fucidin cream treated (positive control), and the negative control group which received no treatment. Four linear-shape, full thickness wounds with 15 mm in length were made in both sides of backbone. Tissue samples were obtained at the end of 4, 7 and 14 days from all groups and were stained with hematoxylin and eosin, then were reviewed under light microscope. The histopathological parameters including inflammatory cells infiltration, reepithelialization, and surface closure rates. The data was analyzed, and P< 0.05 was considered statistically significant. RESULTS Flaxseed treated animals showed higher rate of surface closure, re-epithelialization, and reduced inflammatory cell infiltration compared to control group, particularly in 7th day interval. CONCLUSION Topical administration of Flaxseed promoted the healing process by shortening inflammation phase, elevating surface closure rate, and promoting re-epithelialization process, suggested flaxseed as an effective herbal drug for wound in skin.