Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells

• Main Authors: Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Tan, Huan Huan, Chan, Kok Meng, Tan, Si Jie, Leong, Sze Wei, Mansor, Ahmad Hasnan, Yamin, Bohari M., Lam, Kok Wai
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2016
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73761/1/Kamal%20Rullah%2010.pdf; http://irep.iium.edu.my/73761/; https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra12754a#!divAbstract

Melanin is a form of pigment that gives colour to human skin, hair and eyes. Whilst it protects against skin damage from the sun, accumulation of excessive amounts of epidermal melanin can lead to various dermatological disorders. This study aimed to evaluate the effects of three selected oxadiazo...