Cytomegalovirus impact on elderlies’ vaccination response
Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to chang...
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| Main Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
IIUM Press, International Islamic University Malaysia
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf http://irep.iium.edu.my/73540/ |
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| Summary: | Disease burden from the Malaysian elderly population is increasing as demographics
shifts towards longer life expectancy. It is increasingly evident that immunosenescence
is the central process in many age-related illnesses. Latent human cytomegalovirus
(HCMV) infection had been shown to change the immune system in similar ways to
aging, by causing chronic antigenic stress. However, direct evidence on the impact of
such changes on health remains contentious due to limited data, variable population
backgrounds and individual responses to HCMV. In this study among 59 elderly people
in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on
immunosenescence was assessed using Influenza vaccination response via
haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre
of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and
history of significant infection was also studied as contributing factors. It was found
that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower
response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). |
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