Inflammatory response of bioscaffolds decellularized by sonication treatment
Decellularization of sonication system efficiency is dictated by evaluation of host immune response on scaffolds. This aim of this study is to examine the inflammatory response after implantation of bioscaffolds decellularized by sonication treatment at 35 days postsurgery in rats. In this study,...
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| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
Springer
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/72879/14/72879%20Inflammatory%20Response.pdf http://irep.iium.edu.my/72879/2/72879%20Inflammatory%20Response%20of%20Bioscaffolds%20Decellularized%20SCOPUS.pdf http://irep.iium.edu.my/72879/ https://link.springer.com/chapter/10.1007/978-981-10-7554-4_32 |
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| Summary: | Decellularization of sonication system efficiency is dictated by evaluation of host immune
response on scaffolds. This aim of this study is to examine the inflammatory response
after implantation of bioscaffolds decellularized by sonication treatment at 35 days postsurgery in rats. In this study, aortic tissues decellularized by sonication treatment in 0.1
and 2% of Sodium Dodecyl Sulfate (SDS) detergents. Samples were washed for 5 days in
Phosphate Buffer Saline (PBS) following decellularization. Samples were implanted in on
the lower right thoracic cavity of rats for 35 days. To examine the inflammatory response,
the implanted samples were explanted and evaluated histologically by Hematoxylin
Eosin (H-E) staining. From the histological analysis, bioscaffolds decellularized by
sonication treatment in response to macrophages shows the minimal inflammatory
response. Minimal inflammatory response elicits by bioscaffolds suggests the safety of
bioscaffolds prepared by sonication treatment as biomedical implants. |
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