Formulation of dispersed gliclazide powder in polyethylene glycol–polyvinyl caprolactam– polyvinyl acetate grafted copolymer carrier for capsulation and improved dissolution

• Main Authors: Ahmed Mahdi Dukhan, Ather, Mohamad Yusoff, Nursazreen Amalina, Kyaw Oo, May, Sengupta, Pinaki, Doolaanea, Abd Almonem, Aljapairai, Khater Ahmed Saeed, Chatterjee, Bappaditya
• Format: Article
• Language: English
• Published: Association of Pharmaceutical Teachers of India 2018
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/67672/1/IJPER_4_18-QC-RD.pdf; http://irep.iium.edu.my/67672/; http://ijper.org/sites/default/files/IndJPhaEdRes_52_4-s210_0.pdf

Background: Oral bioavailability of gliclazide, a hypoglycemic drug, is hindered by its low aqueous solubility. Improvement of solubility will enhance dissolution rate and in turn the bioavailability. This research aimed to formulate the solid dispersed gliclazide using a novel polyethylene glycol–p...