Topical co-delivery of indomethacin and nigella sativa L. essential oil in poly-cappa-caprolactone nanoparticles: in vitro study of anti-inflammatory activity

• Main Authors: Badri, Waisudin, Mohamed, Farahidah, Mohd Shafri, Mohd Affendi, El Asbahani, A., Miladi, Karim, Nazari, Qand Agha, Viennet, Celine, Robin, Sophie, Fessi, Hatem, Elaissari, Abdelhamid
• Format: Article
• Language: English
• Published: International Journal of Advanced Research (IJAR) 2018
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/66791/1/443_IJAR%20indomethacin%20microparticles.pdf; http://irep.iium.edu.my/66791/; http://www.journalijar.com/uploads/443_IJAR-22995.pdf

Indomethacin is a potent, nonselective Non-steroidal Antiinflammatory Drug (NSAID) but its low water-solubility precludes its use as topical dosage form. As with other NSAIDs, the systemic delivery is associated with high risk of serious gastrointestinal adverse events including bleeding, ulcera...