Cytotoxic, antiproliferative and apoptosis-inducing activity of L-amino acid oxidase from Malaysian Calloselasma rhodostoma on human colon cancer cells

• Main Authors: Zainal Abidin, Syafiq Asnawi, Rajadurai, Pathmanathan, Chowdhury, Md. Ezharul Hoque, Ahmad Rusmili, Muhamad Rusdi, Othman, Iekhsan, Naidu, Rakesh
• Format: Article
• Language: English; English
• Published: Wiley-Blackwell 2018
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/65885/19/65885_Cytotoxic%2C%20Antiproliferative%20and%20Apoptosis-inducing_complete.pdf; http://irep.iium.edu.my/65885/13/65885_Cytotoxic%2C%20Antiproliferative%20and%20Apoptosis-inducing_SCOPUS.pdf; http://irep.iium.edu.my/65885/; https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13060

The aim of this study was to investigate the cytotoxic, antiproliferative activity and the induction of apoptosis by L-amino acid oxidase isolated from Calloselasma rhodostoma crude venom (CR-LAAO) on human colon cancer cells. CR-LAAO was purified using three chromatographic steps: molecular exclus...