GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

• Main Authors: Ferro, Riccardo, Adamska, Aleksandra, Lattanzio, Rossano, Mavrommati, Ioanna, Edling, Charlotte E., Ahmad Arifin, Syamsul, Fyffe, Chanse A., Sala, Gianluca, Sacchetto, L., Chiorino, Giovanna, De Laurenzi, Vincenzo, Piantelli, Mauro, Sansom, Owen, Maffucci, Tania, Falasca, Marco
• Format: Article
• Language: English; English
• Published: Nature Publishing Group 2018
• Subjects: RM147 Administration of Drugs and Other Therapeutic Agents; RM283 Endocrinotheraphy; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/65709/1/65709_GPR55%20signalling%20promotes.pdf; http://irep.iium.edu.my/65709/2/65709_GPR55%20signalling%20promotes_SCOPUS%20in%20press.pdf; http://irep.iium.edu.my/65709/; https://www.nature.com/articles/s41388-018-0390-1

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new thera...