Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence

• Main Authors: Ridzwan, Irna Elina, Suhaimi, Maryam Saadah, Wasli, Nur Syafinaz, Kasmuri, Abdul Razak, Azzubaidi, Marwan Saad, Hashim, Ridzwan, Ahmed, Qamar Uddin, Ming, Long Chiau, Mohamed, Nornisah, Syd Mohmad Faudzi, Syed Mohd Syahmi
• Format: Article
• Language: English
• Published: University of Huddersfield Press 2017
• Subjects: RM300 Drugs and their action; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/64949/3/Article.pdf; http://irep.iium.edu.my/64949/; http://eprints.hud.ac.uk/id/eprint/34610/1/20_APS17_43%20Ridzwan.pdf

A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid...