Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the mini...
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International Islamic University Malaysia
2018
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my.iium.irep.641382018-08-01T03:19:18Z http://irep.iium.edu.my/64138/ Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita QR Microbiology QR180 Immunology Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte (3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles. Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may potentially be used as an alternative therapeutic agent against T. rubrum infections. International Islamic University Malaysia 2018-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64138/1/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_article.pdf application/pdf en http://irep.iium.edu.my/64138/2/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_scopus.pdf application/pdf en http://irep.iium.edu.my/64138/13/64138_Cytotoxicity%20and%20antifungal%20properties_WoS.pdf Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and Abdul Rahman, Nor Iza and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2018) Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum. International Medical Journal Malaysia, 17 (1). pp. 31-36. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p031036.pdf |
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QR Microbiology QR180 Immunology Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
description |
Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have
antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the
effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory
concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the
treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte
(3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the
HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles.
Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may
potentially be used as an alternative therapeutic agent against T. rubrum infections. |
format |
Article |
author |
Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita |
author_facet |
Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita |
author_sort |
Ridzuan, P. M. |
title |
Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
title_short |
Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
title_full |
Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
title_fullStr |
Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
title_full_unstemmed |
Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
title_sort |
cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum |
publisher |
International Islamic University Malaysia |
publishDate |
2018 |
url |
http://irep.iium.edu.my/64138/1/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_article.pdf http://irep.iium.edu.my/64138/2/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_scopus.pdf http://irep.iium.edu.my/64138/13/64138_Cytotoxicity%20and%20antifungal%20properties_WoS.pdf http://irep.iium.edu.my/64138/ http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p031036.pdf |
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1643617415215448064 |
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13.19449 |