Development and validation of bioanalytical method for the analysis of amlodipine in human plasma with optimized extraction method using design of experiment

• Main Authors: Mohammed Helaluddin, Abul Bashar, Alaama, Mohamed, Awang, Mohamed, Abbas, Syed Atif
• Format: Article
• Language: English; English; English
• Published: Colegio de Farmaceuticos de la Provincia de Buenos Aires 2018
• Subjects: RB Pathology; RM Therapeutics. Pharmacology; RM695 Physical medicine. Physical therapy
• Online Access: http://irep.iium.edu.my/63896/1/63896_Development%20and%20Validation%20of%20Bioanalytical%20Method_article.pdf; http://irep.iium.edu.my/63896/2/63896_Development%20and%20Validation%20of%20Bioanalytical%20Method_scopus.pdf; http://irep.iium.edu.my/63896/13/63896_Development%20and%20validation%20of%20bioanalytical%20method_WoS.pdf; http://irep.iium.edu.my/63896/; http://www.latamjpharm.org/previous_issue.php?vol=37&num=1

SUMMARY. Amlodipine is antihypertensive drug belonging to calcium antagonist group. This study aims to apply experimental design for the optimization of extraction method of amlodipine from human plasma for higher and constant recovery. A chromatographic method involving HPLC (High Performance Liq...