Comparative assessment of plasmid DNA delivery by encapsulation within or adsorbed on poly (D, L-lactide-co-glycolide) nanoparticles

• Main Authors: Doolaanea, Abd Almonem, Mansor, Nur 'Izzati, Mohd Nor, Nurul Hafizah, Mohd Shafri, Mohd Affendi, Mohamed, Farahidah
• Format: Article
• Language: English; English; English
• Published: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria 2018
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/62375/1/Comparative%20assessment%20of%20plasmid%20DNA%20delivery.pdf; http://irep.iium.edu.my/62375/7/62375-Comparative%20assessment%20of%20plasmid%20DNA%20delivery-SCOPUS.pdf; http://irep.iium.edu.my/62375/13/62375_Comparative%20assessment%20of%20plasmid%20DNA%20delivery%20by%20encapsulation%20within%20or%20adsorbed%20on%20poly%20%28D%2C%20L-lactide-co-glycolide%29%20nanoparticles_WOS.pdf; http://irep.iium.edu.my/62375/; https://www.tjpr.org/admin/12389900798187/2018_17_1_1.pdf

Purpose: To compare the gene delivery effectiveness of plasmid DNA (pDNA) encapsulated within poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles with that adsorbed on PLGA nanoparticles. Methods: PLGA nanoparticles were prepared using solvent-evaporation method. To encapsulate pDNA within the p...