Understanding the significance variables for fabrication of fish gelatin nanoparticles by Plackett-Burman design

The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta p...

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Main Authors: Subara, Deni, Jaswir, Irwandi, Al-Khatib, Ma'an Fahmi Rashid, Noorbatcha, Ibrahim Ali
格式: Proceeding Paper
語言:English
English
出版: IOP Publishing 2017
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在線閱讀:http://irep.iium.edu.my/61900/1/FGNP_2018_IOP_Conf._Ser._Mater._Sci._Eng._290_012006.pdf
http://irep.iium.edu.my/61900/7/61900_Understanding%20the%20significance%20variables%20for%20fabrication_scopus.pdf
http://irep.iium.edu.my/61900/
http://iopscience.iop.org/article/10.1088/1757-899X/290/1/012006
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總結:The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta potential were found in the range 240±9.76 nm, 0.3, and −9 mV, respectively. Statistical results explained that concentration of acetone, pH of solution during precipitation step and volume of cross linker had a most significant effect on particles size of fish gelatin nanoparticles. It was found that, time and chemical consuming is lower than previous research. This study revealed the potential of quality-by design in understanding the effects of process variables on the fish gelatin nanoparticles production.