Statins and ischaemia reperfusion injury: a molecular biological review

• Main Authors: Abdul Rahman, Mohd Norhisham Azmi, Chetter, Ian Clifford
• Format: Article
• Language: English; English
• Published: Bentham Science Publishers B.V. 2010
• Subjects: RD Surgery
• Online Access: http://irep.iium.edu.my/59118/1/Statins%20and%20ischaemia%20reperfusion%20injury%20a%20molecular%20biological%20review.pdf; http://irep.iium.edu.my/59118/7/59118_Statins%20and%20ischaemia%20reperfusion%20injury_scopus.pdf; http://irep.iium.edu.my/59118/; https://benthamscience.com/journals/current-vascular-pharmacology/

The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are a class of drug used to lower low-density lipoprotein (LDL) levels. However, in recent years, statins have been shown to possess a pleiotropic effect beyond its cholesterol lowering ability, including attenuating the effect of ischaemia reperfusion injury. This review considers the biomolecular processes that may lead to this beneficial effect.