α‐Glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and LC–MS/MS profiling of the active cultivar

• Main Authors: Lawal, Umar, Leong, Sze Wei, Saari, Khozirah, Ismail, Intan Safinar, Khatib, Alfi, Abas, Faridah
• Format: Article
• Language: English; English
• Published: Wiley Periodicals, Inc. 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/59006/1/lawal%20et%20al.%202017.pdf; http://irep.iium.edu.my/59006/6/59006_%CE%B1-Glucosidase%20Inhibitory%20and%20Antioxidant%20Activities%20of%20Different%20Ipomoea%20aquatica%20Cultivars%20_scopus.pdf; http://irep.iium.edu.my/59006/; http://onlinelibrary.wiley.com/doi/10.1111/jfbc.12303/abstract

The present study was designed to investigate the effect of Ipomoea aquatica extracted using water and methanol at various concentrations on the total phenolics, antioxidant capacity, and a-glucosidase inhibitory activities. Three I. aquatica cultivars were used in this study including the upland type with narrow leaves (K-11), low-land aquatic types with broader shaped leaves (K-25), and bamboo-shaped leaves (K-88). The results revealed that 70% methanol extract of K-11 showed higher total phenolic content and a-glucosidase inhibitory and antioxidant activities than the other two cultivars. The phytochemical constituents in the active extract K-11 were analyzed by means of liquid chromatography coupled with diode array detection and electrospray tandem mass spectroscopy. Eighteen compounds were detected of which 13 were tentatively identified as quercetin-3-O-sophoroside, quercetin-3-O-glucoside, quercetin-3,7-di-O-glucoside, nomilinic acid glucoside, 4,5-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, luteolin-7-glucoside and 3,4,5-tricaffeolquinic acid, fatty acid together with quercetin, and tricaffeoylquinic acid derivatives.