Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics

• Main Authors: Win, Thazin, Rajagopal, JeevanRaj, Mandal, Uttam Kumar, Sengupta, Pinaki, Chatterjee, Bappaditya
• Format: Article
• Language: English; English; English
• Published: Latin American Journal of Pharmacy 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf; http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf; http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf; http://irep.iium.edu.my/58691/

The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product.