Does HLA-B*27 subtypes and ethnicity matter in Ankylosing Spondylitis?

• Main Authors: Sulaiman, Salsabil, Too, Chun Lai, Tan, Lay Kim Tan, Ahmad Fauzi, Nurul Aain, Hussein, Heselynn, Rajalingam, Shamala, Sularman, Wahinuddin, Ong, Ping Seung, Rosman, Azmillah, Mohd. Zain, Mollyza, Lau, Ing Soo, Gun, Suk Chyn, Tan, Bee Eng, Chong, Hwee Cheng, Abdullah, Hilmi, Mohamad, Asmah, Mohamed Ismail, Asmahan, Loh, Yet Lin, Lim, Ai Lee, Hamad, Nor Shahrazat, Teh, Cheng Lay, Ling, Guo Ruey, Chong, Eleen,Yun Ying, Murad, Shanaz
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2017
• Subjects: RC Internal medicine
• Online Access: http://irep.iium.edu.my/58570/7/58570-Program%20book.pdf; http://irep.iium.edu.my/58570/1/170428_KCR_HLA-B27%20SUBTYPE%20%26%20ETHNICITY%20IN%20AS_Salsabil%20Sulaiman_FV.pdf; http://irep.iium.edu.my/58570/; http://www.kcr2017.com/register/2017_spring/file/Program_Book.pdf

Ankylosing Spondylitis (AS) is a chronic, progressive inflammatory disorder that results in ankylosis of the vertebral column and sacroiliac joints.  More than 30% of patients with AS carry a heavy burden of disease and have a decreased quality of life.  The HLA-B*27 is a well known genetic risk variant for ankylosing spondylitis (AS).  However, the degree of association varies for different subtypes and depends on ethnicity.  Malaysia is a multi-ethnic country comprises Malays as the largest ethnic group, followed by Chinese, Indians and mixed-ethnicities.