A review of anticancer, antitumor, and antioxidant of clinacanthus nutans

• Main Authors: Zakaria, Khairun Najwa, Amid, Azura, Jamal, Parveen
• Format: Article
• Language: English; English; English
• Published: Institute of Research Management and Consultancy University of Malaya and Malaysian Society for Molecular Biology and Biotechnology 2017
• Subjects: TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/57630/6/Scan_20170719.pdf; http://irep.iium.edu.my/57630/11/57630_A%20review%20of%20anticancer.pdf; http://irep.iium.edu.my/57630/17/57630_A%20review%20of%20anticancer%2C%20antitumor%2C%20and%20antioxidant_SCOPUS.pdf; http://irep.iium.edu.my/57630/; http://www.msmbb.org.my/apjmbb/html251/251d.pdf

Clinacanthus nutans (CN) often use as herbal remedies complementary. The extracts from its dried leaves have been used traditionally to treat disease such as anti-venom for a snake / insect bite and reduce mild fever. A literature search showed that the ethanol extract of CN demonstrated an antioxidant activity and exhibited a protective effect against free radical. Experimental evidence confirmed that CN extract is used in treating tumor and cancer since it showed anticancer and anti-proliferative properties in vitro and in vivo. CN bioactive compounds demonstrated cytotoxic, anti-proliferative and antioxidant properties against cultured cancer cell lines, suggesting that CN is a suitable alternative for cancer prevention or treatment. CN is a good subject to be studied in the anticancer discovery area and hold great potential for being exploited as a chemopreventive drug since it possesses encouraging results with all the in vivo and in vitro tests carried out by many researchers