Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles

• Main Authors: Mohamed Suffian, Izzat Fahimuddin, Nishimura, Yuya, Morita, Kenta, Nakamura-Tsuruta, Sachiko, Al-Jamal, Khuloud, Ishii, Jun, Ogino, Chiaki, Kondo, Akihiko
• Format: Article
• Language: English
• Published: Biomed Central 2015
• Subjects: QH301 Biology; QR355 Virology; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/57364/1/Suffian%20et%20al.%20Journal%20of%20Nanobiotechnology.pdf; http://irep.iium.edu.my/57364/; http://dx.doi.org/10.1186/s12951-015-0074-8

BACKGROUND: The hepatitis B virus core (HBc) particle is known as a promising new carrier for the delivery of drugs and nucleic acids. However, since the arginine-rich domain that is located in the C-terminal region of the HBc monomer binds to the heparan sulphate proteoglycan on the cell surface du...