Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

• Main Authors: Edueng, Khadijah, Mahlin, Denny, Larsson, Per Olof, Bergström, Christel A.S.
• Format: Article
• Language: English; English
• Published: Elsevier B.V. 2017
• Subjects: R Medicine (General); RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/57294/1/57294_Mechanism-based%20selection_new.pdf; http://irep.iium.edu.my/57294/2/57294_Mechanism-based%20selection_SCOPUS.pdf; http://irep.iium.edu.my/57294/; http://ac.els-cdn.com/S0168365917305345/1-s2.0-S0168365917305345-main.pdf?_tid=67924602-5228-11e7-ae80-00000aab0f6c&acdnat=1497572095_ab01db0b32d121e8baa77db1d9d6ff32

We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crysta...