Enhancement of the immediate release of paracetamol from alginate beads
Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the releas...
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my.iium.irep.572642018-04-20T08:57:54Z http://irep.iium.edu.my/57264/ Enhancement of the immediate release of paracetamol from alginate beads Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem RS Pharmacy and materia medica Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the release in the acidic pH. Methods: The beads were prepared by dropwise paracetamol/alginate suspension in divalent cation solution. Two attempts were used to increase the dissolution of paracetamol in the acidic pH. First attempt was by only changing preparation variables: needle size, alginate viscosity and drug loading using 23 full factorial design. The second approach was by adding excipients like carbopol, tween and polyethylene glycol. The beads were characterized for their size, encapsulation efficiency and release profile. Results: First approach, changing preparation variables without excipient adding, helped to increase the drug release in the acid but to a maximum of 26% using a smaller needle, lower drug loading and higher alginate viscosity. However, optimising the formulation with suitable excipients increased the drug release in the acid to 77.3%. The optimised formulation included carbopol 940 (pH sensitive polymer) and tween 80 (facilitates water entry) in the beads, with using barium chloride instead of calcium chloride together with PEG 400 in the complexing solution. Conclusion: To achieve immediate release of paracetamol from alginate beads in the acidic pH, excipients need to be added. Rational selection of excipients is critical to achieve the desired drug release. Innovare Academic Sciences Pvt Ltd 2017 Article REM application/pdf en http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf application/pdf en http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf Hamed, Samah and Ayob, Farah Amalina and Alfatama, Mulham and Doolaanea, Abd Almonem (2017) Enhancement of the immediate release of paracetamol from alginate beads. International Journal of Applied Pharmaceutics, 9 (2). pp. 47-51. ISSN 0975-7058 https://innovareacademics.in/journals/index.php/ijap/article/viewFile/15672/10165.pdf 10.22159/ijap.2017v9i2.15672 |
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RS Pharmacy and materia medica Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem Enhancement of the immediate release of paracetamol from alginate beads |
description |
Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs
administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the
release in the acidic pH.
Methods: The beads were prepared by dropwise paracetamol/alginate suspension in divalent cation solution. Two attempts were used to increase
the dissolution of paracetamol in the acidic pH. First attempt was by only changing preparation variables: needle size, alginate viscosity and drug
loading using 23 full factorial design. The second approach was by adding excipients like carbopol, tween and polyethylene glycol. The beads were
characterized for their size, encapsulation efficiency and release profile.
Results: First approach, changing preparation variables without excipient adding, helped to increase the drug release in the acid but to a maximum
of 26% using a smaller needle, lower drug loading and higher alginate viscosity. However, optimising the formulation with suitable excipients
increased the drug release in the acid to 77.3%. The optimised formulation included carbopol 940 (pH sensitive polymer) and tween 80 (facilitates
water entry) in the beads, with using barium chloride instead of calcium chloride together with PEG 400 in the complexing solution.
Conclusion: To achieve immediate release of paracetamol from alginate beads in the acidic pH, excipients need to be added. Rational selection of
excipients is critical to achieve the desired drug release. |
format |
Article |
author |
Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem |
author_facet |
Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem |
author_sort |
Hamed, Samah |
title |
Enhancement of the immediate release of paracetamol from alginate beads |
title_short |
Enhancement of the immediate release of paracetamol from alginate beads |
title_full |
Enhancement of the immediate release of paracetamol from alginate beads |
title_fullStr |
Enhancement of the immediate release of paracetamol from alginate beads |
title_full_unstemmed |
Enhancement of the immediate release of paracetamol from alginate beads |
title_sort |
enhancement of the immediate release of paracetamol from alginate beads |
publisher |
Innovare Academic Sciences Pvt Ltd |
publishDate |
2017 |
url |
http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf http://irep.iium.edu.my/57264/ https://innovareacademics.in/journals/index.php/ijap/article/viewFile/15672/10165.pdf |
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1643615105562181632 |
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13.18916 |