Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

• Main Authors: Mohamad Zin, Noraziah, Baba, Mohd Shukri, Zainal-Abidin, Abu Hassan, Latip, Jalifah, Mazlan, Noor Wini, RuAngelie, Edrada-Ebel
• Format: Article
• Language: English; English; English
• Published: Dove Medical Press Ltd. 2017
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf; http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf; http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf; http://irep.iium.edu.my/57103/; https://www.dovepress.com/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-a-peer-reviewed-fulltext-article-DDDT

Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmod...