Thyroxine (T4) transfer from blood to cerebrospinal fluid in sheep isolated perfused choroid plexus: role of multidrug resistance-associated Proteins and Organic anion Transporting Polypeptides

• Main Authors: Zibara, Kazem, El Zein, Nabil, Sabra, Mirna, Hneino, Mohammad, Harati, Hayat, Mohamed, Wael Mohamed Yousef, Kobeissy, Firas H., Kassem, Nouhad
• Format: Article
• Language: English; English; English
• Published: Frontiers Media SA 2017
• Subjects: RZ400 Mental healing
• Online Access: http://irep.iium.edu.my/57047/1/fneur-08-00214.pdf; http://irep.iium.edu.my/57047/7/57047_Thyroxine%20%28T4%29%20transfer%20from%20blood%20to%20cerebrospinal_Scopus.pdf; http://irep.iium.edu.my/57047/13/57047_Thyroxine%20transfer%20from%20blood%20to%20cerebrospinal_WOS.pdf; http://irep.iium.edu.my/57047/; http://journal.frontiersin.org/journal/neurology#articles

Thyroxine (T4) enters the brain either directly across the blood–brain barrier (BBB) or indirectly via the choroid plexus (CP), which forms the blood–cerebrospinal fluid barrier (B-CSF-B). In this study, using isolated perfused CP of the sheep by single-circulation paired tracer and steady-state...