MGMT and SPOCK2 promoter methylation in diffuse large B-Cell lymphoma: a study in two tertiary health centres in the East Coast of Malaysia = Metilasi promoter MGMT dan SPOCK2 dalam diffuse large B-cell lymphoma: satu kajian yang dijalankan di dua pusat Kesihatan di Pantai Timur Malaysia

• Main Authors: Zainuddin, Norafiza, Mohd. Ridah, Lailatul Jalilah, Omar, Aqilah Nabihah, A. Talib, Norlelawati, Muhammad, Siti Aeshah @ Naznin, Hussain, Faezahtul Arbaeyah
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2017
• Subjects: RB Pathology; RC254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/56529/1/56529_MGMT%20and%20SPOCK2%20Promoter%20Methylation.pdf; http://irep.iium.edu.my/56529/; http://ejournal.ukm.my/jskm/article/view/16313; http://dx.doi.org./10.17576/JSKM-2017-1502-10

MGMT (O6-Methylguanine-DNA Methyltransferase) suppresses tumor development by removing alkyl adduct, while SPOCK2 (SPARC/Osteonectin CWCV and Kazal-like domains proteoglycan) abolishes the inhibition of membrane-type matrix metalloproteinases (MT-MMP) which leads to angiogenesis. Hence, MGMT methyla...