Methylation status of MGMT and SPOCK2 in diffuse large B-cell lymphoma

• Main Authors: Zainuddin, Norafiza, Mohd. Ridah, Lailatul Jalilah, Omar, Aqilah Nabihah, A. Talib, Norlelawati, Muhammad, Naznin, Hussain, Faezatul Arbaeyah
• Format: Conference or Workshop Item
• Language: English
• Published: 2016
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/54375/1/54375_abstract.pdf; http://irep.iium.edu.my/54375/; https://sites.google.com/site/3rdpabsc2016/

MGMT (O6-Methylguanine-DNA Methyltransferase) suppresses tumour development by removing alkyl adduct, while SPOCK2 (SPARC/Osteonectin CWCV and Kazal-like domains proteoglycan) abolishes the inhibition of membrane-type matrix metalloproteinases (MT-MMP) which leads to angiogenesis. Hence, MGMT methyl...