Pyrosequencing-based quantitative identification of p16 methylation in diffuse large b-cell lymphoma at two centres in the east coast of malaysia

• Main Authors: Mohd. Ridah, Lailatul Jalilah, Ismail, Aziah, A. Talib, Norlelawati, Muhammad, Siti Aeshah @ Naznin, Hussain, Faezahtul Arbaiyah, Zainuddin, Norafiza
• Format: Article
• Language: English
• Published: Universiti Sains Malaysia 2016
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/54196/1/NZ_JCBS_61-58-PB.pdf; http://irep.iium.edu.my/54196/; http://apps.amdi.usm.my/journal/index.php/jbcs/index

Introduction: Methylation of promoter region of p16 leading to gene silencing has been implicated in a wide range of malignancies including lymphomas. In diffuse large B cell lymphoma (DLBCL) particularly, a varying percentage of epigenetic inactivation of p16 promoter region was observed ranging f...