Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
Introduction: Nigella sativa has been reported to have anti-inflammatory and antioxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with...
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| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
IIUM
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/52994/18/52994.pdf http://irep.iium.edu.my/52994/19/52994_brochure http://irep.iium.edu.my/52994/ http://iiumedic.net/imjm/v1/ |
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| Summary: | Introduction: Nigella sativa has been reported to have anti-inflammatory and antioxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on
the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were
used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks.
The rats with HFD groups were subsequently randomly divided again into 4 groups. One
group was continued with HFD while the other 3 groups were continued with the HFD in
addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1
and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological
assessment of liver were subsequently performed. Results: Animals fed with HFD had
increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin,
cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin
ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with
Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but
reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at
the higher doses displayed much better effect. Histologically the liver in all groups
exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the
dyslipidaemia in animal models with HFD.
KEYWORDS: Nigella sativa, high fat diet, dyslipidaemia |
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