VKORC1 Haplotypes in patients treated with warfarin

• Main Authors: Beshna, E, Teh , Lay Kek, Ngow, Harris Abdullah, Harun, Roslan, Salleh, Mohd Zaki
• Format: Conference or Workshop Item
• Language: English
• Published: 2010
• Subjects: RC Internal medicine; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/5241/1/Pharmacogenomic_VKROC1_Halotype_Abstract_Poster.pdf; http://irep.iium.edu.my/5241/

Background: Warfarin has very narrow therapeutic windows and large individual variability. Genetic variants encoding VKORC1 gene has resulted in altered sensitivity to warfarin or warfarin resistance. Nine haplotypes (H1-H9) of VKORC1 had been categorized with reference to 10 SNPs (Gen Bank accessio...