Molecular mechanisms underlying the effect of pioglitazone therapy in Non-Alcoholic Steatohepatitis (NASH)

• Main Authors: Abdul Rahim, Roslina, Aithal, Guruprasad Padur, Macdonald, Ian A., Bennett, Andrew J.
• Format: Article
• Language: English
• Published: Elsevier, Inc. 2009
• Subjects: R Medicine (General); RA Public aspects of medicine; RB Pathology; RC Internal medicine; RT Nursing
• Online Access: http://irep.iium.edu.my/52366/1/EASL%202009.pdf; http://irep.iium.edu.my/52366/; http://www.journal-of-hepatology.eu/article/S0168-8278(09)60694-2/abstract

Background and Aim: A recent randomised double-blind placebocontrolled trial (RCT) demonstrated that Pioglitazone therapy was effective in reducing hepatocellular injury and fibrosis in subjects with NASH. We aimed to investigate the molecular mechanisms underlying the effects of Pioglitazone in...