High occurrence of CYP3A5 variants among breast cancer and organ transplant patients

• Main Authors: Ismail, S, Mohammad, NI, Hamzah, S, Mohamad , R, Harun, R, Suhaimi, S, Jaszle, S, Sood, S, Henry, F, Shabery, A, Rajoo, T, Bahri, R, Muniandy, S, Ismail, G, Wong, H. S., Abdullah Ngow, Harris, U Kyaw, T. H., Jalaludin, K, Din, J, Hatta, F. H., Teh, L. K., Salleh, M. Z.
• Format: Conference or Workshop Item
• Language: English
• Published: 2010
• Subjects: RB Pathology; RC Internal medicine
• Online Access: http://irep.iium.edu.my/5235/1/Abstract_for_NCCR_2010_cyp3a5a.pdf; http://irep.iium.edu.my/5235/; http://www.nccr.gov.my/index.cfm?menuid=28

Abstract CYP3A5 is one of the important drug metabolising enzyme and its polymorphism shows marked differences in protein expression and catalytic activities between different geographical ethnic groups. Both tamoxifen and tacrolimus are substrates of CYP3A5 and thus the polymorphism may cause phar...