Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescr...
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my.iium.irep.523462016-10-18T02:04:28Z http://irep.iium.edu.my/52346/ Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review Ismail, Fadhilah Zin, Che Suraya RS Pharmacy and materia medica Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescription opioids. Objective: This review examined factors associated with prescription opioid overdose deaths in patients with non-cancer pain. Method: A comprehensive literature search was conducted for studies published from 2004 to 2014 using databases such as Science Direct, PubMed, Web of Science, Cochrane review and Scopus. Articles were included if they were original research studies written in English that reported deaths with prescription opioid overdose in patients with non-cancer pain. Results: A total of 18 studies met the inclusion criteria and were included. Fndings from the review demonstrated that concomitant use of opioids with benzodiazepines (polysubstance use) was the main factor associated with opioid ODs. Codeine and oxycodone were more commonly reported to cause opioid ODs and opioid doses of more than 100 mg per day in morphine equivalents have higher risk to cause ODs. Other factors included male patients, middle aged and having mental illness. Conclusion: Prescription opioid overdose deaths were primarily caused by concomitant use of opioid with benzodiazepines. Further research is required to examine the trend and patterns of this co-prescribing. The guidelines on opioid prescribing and education on opioids for both patients and physicians should be emphasized to reduce fatalities from overdose while enhancing the safe prescribing of opioids. 2015 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/52346/1/1601017__%20poster_MPS_all.pdf application/pdf en http://irep.iium.edu.my/52346/7/52346.pdf Ismail, Fadhilah and Zin, Che Suraya (2015) Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review. In: 12th MPS Pharmacy Scientific Conference 2015 (MPS-PSC 2015), 13th-15th November 2015, Subang Jaya, Selangor. (Unpublished) |
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RS Pharmacy and materia medica Ismail, Fadhilah Zin, Che Suraya Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
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Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescription opioids. Objective: This review examined factors associated with prescription opioid overdose deaths in patients with non-cancer pain. Method: A comprehensive literature search was conducted for studies published from 2004 to 2014 using databases such as Science Direct, PubMed, Web of Science, Cochrane review and Scopus. Articles were included if they were original research studies written in English that reported deaths with prescription opioid overdose in patients with non-cancer pain. Results: A total of 18 studies met the inclusion criteria and were included. Fndings from the review demonstrated that concomitant use of opioids with benzodiazepines (polysubstance use) was the main factor associated with opioid ODs. Codeine and oxycodone were more commonly reported to cause opioid ODs and opioid doses of more than 100 mg per day in morphine equivalents have higher risk to cause ODs. Other factors included male patients, middle aged and having mental illness. Conclusion: Prescription opioid overdose deaths were primarily caused by concomitant use of opioid with benzodiazepines. Further research is required to examine the trend and patterns of this co-prescribing. The guidelines on opioid prescribing and education on opioids for both patients and physicians should be emphasized to reduce fatalities from overdose while enhancing the safe prescribing of opioids. |
format |
Conference or Workshop Item |
author |
Ismail, Fadhilah Zin, Che Suraya |
author_facet |
Ismail, Fadhilah Zin, Che Suraya |
author_sort |
Ismail, Fadhilah |
title |
Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
title_short |
Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
title_full |
Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
title_fullStr |
Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
title_full_unstemmed |
Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review |
title_sort |
factors associated with prescription opioid overdose deaths in patients with non-cancer pain: a literature review |
publishDate |
2015 |
url |
http://irep.iium.edu.my/52346/1/1601017__%20poster_MPS_all.pdf http://irep.iium.edu.my/52346/7/52346.pdf http://irep.iium.edu.my/52346/ |
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1643614145832026112 |
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13.18916 |