A review on anticancer and biochemical properties of Clinacanthus nutans
Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect bite. Phytochemical screening showed that the extract comprises of lupeol, –sitost...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Kulliyah of Engineering, International Islamic University Malaysia
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51801/1/51801.pdf http://irep.iium.edu.my/51801/ http://www.iium.edu.my/icbioe/2016/ |
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| Summary: | Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The
extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect
bite. Phytochemical screening showed that the extract comprises of lupeol, –sitosterol, stigmasterol, Botulin,
myricyl alcohol C-glycosyl flavones (vitexin, isovitexin, shaftoside, isomollupentin 7-O-b -glucopyranoside,
orientin and isoorientin), sulfur-containing glucosides, cerebrosides mixer, a monoacylmonogalactosylglycerol,
13-hydroxy-(13-S)-phaeophytin b, Pupurin-18-phytyl ester, phaeophorbide and
chlorophyll derivatives. Literature search showed that the ethanolic extract of CN had an antioxidant activity
and protective effect against free radical. Experimental evidences confirmed that the CN could be used in
treating tumor and cancer since it showed anticancer and antiproliferative properties. Its petroleum ether
extracts also demonstrated the strongest cytotoxic activity against HeLa and K-562 cells. The bioactive
compounds from CN are potential cytotoxic, antioxidant and antiproliferative properties against cultured
cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment. |
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