Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

• Main Authors: Aryal, Prafulla, Abd. Wahab, Mohd. Firdaus, Bucci, Giovanna, Sansom, Mark S.P., Tucker, Stephen J.
• Format: Article
• Language: English
• Published: Taylor and Francis Group, LLC 2015
• Subjects: Q Science (General); QP Physiology
• Online Access: http://irep.iium.edu.my/50082/1/50082.pdf; http://irep.iium.edu.my/50082/; http://www.tandfonline.com/doi/full/10.4161/19336950.2014.981987

Several recent ion channel structures have revealed large side portals, or ‘fenestrations’ at the interface between their transmembrane helices that potentially expose the ion conduction pathway to the lipid core of the bilayer. In a recent study we demonstrated that functional activity of the TWIK-...