Isolation and pharmacological characterization of α-Elapitoxin-Ot1a, a short-chain postsynaptic neurotoxin from the venom of the Western Desert Taipan, Oxyuranus temporalis

• Main Authors: Barber, Carmel M., Ahmad Rusmili, Muhamad Rusdi, Hodgson, Wayne C.
• Format: Article
• Language: English; English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2016
• Subjects: QL Zoology; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/49966/1/Carmel_2016_toxins-08-00058.pdf; http://irep.iium.edu.my/49966/4/49966-Isolation_and_pharmacological_characterization_SCOPUS.pdf; http://irep.iium.edu.my/49966/5/49966-Isolation_and_pharmacological_characterization_WOS.pdf; http://irep.iium.edu.my/49966/; http://www.mdpi.com/2072-6651/8/3/58

Taipans (Oxyuranus spp.) are elapids with highly potent venoms containing presynaptic (β) and postsynaptic (α) neurotoxins. O. temporalis (Western Desert taipan), a newly discovered member of this genus, has been shown to possess venom which displays marked in vitro neurotoxicity. No components have...